ATR (phospho-S428) Rabbit Polyclonal Antibody
| Cat Number: | ABP10098 |
|---|---|
| Conjugate: | Unconjugated |
| Size: | 100 ug |
| Clone: | POLY |
| Concentration: | 1mg/ml |
| Host: | Rabbit |
| Isotype: | IgG |
| Immunogen: | A synthetic phosphorylated peptide around S428 of human ATR. |
| Reactivity: | Hu,man, Mouse, Rat |
| Applications: | Western Blot: 1:100 - 1:500 Immunohistochemistry(paraffin-embedded tissues): 1:50 - 1:200 Immunofluorescence: 1:50 - 1:200 Immunocytochemistry: 1:50 - 1:200 |
| Molecular Weight: | 300kDa |
| Purification: | Affinity purification |
| Synonyms: | FRP1; MEC1; SCKL; FCTCS; SCKL1 |
| Background: | The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1. |
| Form: | Liquid |
| Buffer: | PBS with 0.05% proclin300,50% glycerol,pH7.3. |
| Storage: | Store at -20℃. Avoid repeated freeze-thaw cycles. |