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BACE1

Cat Number: AB-84297
Conjugate: Unconjugated
Size: 100 ug
Clone: POLY
Concentration: 1mg/ml
Host: Rb
Isotype: IgG
Immunogen: allograft inflammatory factor
Reactivity: Hu, Ms, Rt
Applications:

Western Blot: 1:500-1:2000
Immunohistochemistry (paraffin.embedded tissues): 1:20-1:200
Immunoflorescence: 1:50-1:500

Molecular: 17kDa
Purification: Aff. Pur. ≥95% as determined by SDS-PAGE
Synonyms: AIF 1, AIF1, G1, IBA1, IRT 1, Protein G1
Background:

AIF1, also named as G1, IBA1 or daintain/AIF-1, is a 143 amino acid cytoplasmic, inflammation response scaffold protein. It is constitutively expressed in monocytes and macrophages and is known to be involved in macrophage activation. It is a marker of activated macrophage. Despite a lack of detailed knowledge on the in vivo physiological functions of AIF-1, there is growing evidence that shows its aberrant expression contributes to the pathogenesis of many autoimmune diseases, including rheumatoid arthritis. (20944424). AIF1 is an actin-binding protein that enhances membrane ruffling and RAC activation. It enhances lymphocyte migration and the actin-bundling activity of LCP1. AIF1 plays a role in RAC signaling and in phagocytosis and a role in vascular inflammation. AIF1 promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. It is also as a microglial cell marker.

Form: Liquid
Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
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mouse spleen tissue were subjected to SDS PAGE followed by western blot with (IBA1 antibody) at dilution of 1:1000

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Immunohistochemistry of paraffin-embedded human tonsillitis using (IBA1 antibody) at dilution of 1:50

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Immunofluorescent analysis of ( -20℃ Ethanol ) fixed C6 cells using ( IBA1 Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated Goat Anti-Rabbit IgG(H+L)