Beclin-1(5C2)Mouse Monoclonal Antibody
| Cat Number: | MABN07530 |
|---|---|
| Conjugate: | Unconjugated |
| Size: | 100 ug |
| Clone: | 5C2 |
| Concentration: | 1mg/ml |
| Host: | Mouse |
| Isotype: | IgG |
| Immunogen: | Synthetic Peptide of Beclin-1 at AA range of 110-190 |
| Reactivity: | Human,Rat,Mouse,Bovine |
| Applications: | WB 1:1000-1:2000,IHC 1:100-1:200,ICC/IF 1:50-1:200 |
| Molecular: | 60kDa |
| Purification: | Affinity purification |
| Synonyms: | BECN1 |
| Background: | beclin 1(BECN1) Homo sapiens This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015],function:Plays a central role in autophagy (By similarity). May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.,similarity:Belongs to the beclin family.,subcellular location:Expressed in dendrites and cell bodies of cerebellar Purkinje cells.,subunit:Interacts with GOPC and GRID2. Interacts with AMBRA1. Probably forms a complex with AMBRA1 and PIK3C3 (By similarity). Interacts with BCL2 and BCL2L1.,tissue specificity:Ubiquitous. |
| Form: | Liquid |
| Buffer: | Liquid in PBS containing 50% glycerol, 0.5% protective protein and 0.02% New type preservative N. |
| Storage: | Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles. |
Immunohistochemical analysis of paraffin-embedded Human Brain Tissue using Beclin-1 Mouse mAb diluted at 1:200.
Immunohistochemical analysis of paraffin-embedded Human Breast Carcinoma Tissue using Beclin-1 Mouse mAb diluted at 1:200.
Western blot analysis of 1） 293T Cell Lysate, 2） C2C12 Cell Lysate, 3） Rat Brain Tissue Lysate using Beclin-1 Mouse mAb diluted at 1:2000.