C-Myc
| Cat Number: | MAB-10364 |
|---|---|
| Conjugate: | Unconjugated |
| Size: | 100 ug |
| Clone: | 9E10 |
| Concentration: | 1 mg/ml |
| Host: | Ms |
| Isotype: | IgG1 |
| Immunogen: | Synthetic peptide sequence (AEEQKLISEEDLL) corresponding to the C-terminal region of human c-Myc. |
| Reactivity: | Hu |
| Applications: | Flow Cytometry |
| Purification: | Purified by protein-A affinity chromatography |
| Background: | The c-myc gene (8q24 on human chromosome) is the cellular homologue of the v-myc gene originally isolated from an avian myelocytomatosis virus. The c-Myc protein is a transcription factor (nuclear localization). c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin-dependent kinase, ERK2 and C-Jun N-terminal Kinase (JNK) in cell proliferation and cell cycle regulation. In normal cells the expression of c-Myc is tightly regulated but in human cancers c-Myc is frequently deregulated. c-Myc is also essential for tumor cell development in vasculogenesis and angiogenesis that distribute blood throughout the cells. |
| Form: | Liquid |
| Buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage: | Store at 2-8°C. Do not freeze. |
References
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