Cadherin-N
| Cat Number: | MABX-80027 |
|---|---|
| Conjugate: | Unconjugated |
| Size: | 100 ug |
| Clone: | NC-17 |
| Concentration: | 1mg/ml |
| Host: | Ms |
| Isotype: | IgG1 |
| Immunogen: | Affinity purified chicken heart A-CAM. |
| Reactivity: | Hu, Ms, Rt, Rb, Ch |
| Applications: | Western blot At 2μg/ml with the appropriate system to detect N-cadherin in cells and tissues. Immunohistochemistry (Frozen Section) At 4μg/ml to detect N-cadherin in formalin or acetone fixed tissues. |
| Purification: | Purified |
| Background: | N-cadherin(NCAD) is a member of the cadherin cell-cell adhesion receptor family that includes P-, E-, and R-cadherin and liver cell adhesion molecule(L-CAM). N- Cadherin,, also known as Cadherin-2, encodes a 907-amino acid protein that includes a 159-amino acid signal sequence. Human and mouse nucleotide sequences are 96% identical. Mouse Ncad gene consists of 16 exons dispersed over more than 200 kb of genomic DNA. Human N-cadherin gene contains 16 exons and its sequence is highly similar to both the mouse NCAD gene(including the large first and second introns) and other cadherin genes. N-cadherin is mapped to 18q11.2. Cadherin regulates dendritic spine morphogenesis. |
| Form: | Liquid |
| Buffer: | Mouse Ascite fluid, 1,2% sodium acetate 2 mg BSA, with 0.01 mg NaN3 as preservative |
| Storage: | At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing. |