Cyclin H Mouse Monoclonal Antibody
| Cat Number: | MABN85049 |
|---|---|
| Conjugate: | Unconjugated |
| Size: | 100μL |
| Clone: | Monoclonal |
| Concentration: | 1mg/ml |
| Host: | Mouse |
| Isotype: | Mouse IgG2b |
| Immunogen: | Purified recombinant human Cyclin H protein fragments expressed in E.coli. |
| Reactivity: | Human,Mouse |
| Applications: | WB 1:500-1:1000 |
| Molecular: | Calculated MW: 38 kDa; Observed MW: 38 kDa |
| Purification: | Affinity Purification |
| Synonyms: | CCNH; Cyclin-H; MO15-associated protein; p34; p37 |
| Background: | Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. |
| Form: | Liquid |
| Buffer: | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
| Storage: | Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles. |