EHMT2
| Cat Number: | AB-J856 |
|---|---|
| Size: | 100ug |
| Clone: | POLY |
| Concentration: | 1mg/ml |
| Host: | Rb |
| Isotype: | IgG |
| Immunogen: | Synthesized peptide derived from human EHMT2 protein. |
| Reactivity: | Hu, Ms |
| Applications: | Western Blot: 1:500-2000 |
| Molecular Weight: | 133kDa |
| Purification: | EHMT2 antibody was affinity-purified from rabbit antiserum by affinitychromatography using epitope-specific immunogen. |
| Synonyms: | Histone-lysine N-methyltransferase EHMT2 Euchromatic histone-lysine Nmethyltransferase 2 HLA-B-associated transcript 8 Histone H3-K9 methyltransferase 3 H3-K9-HMTase 3 Lysine N-methyltransferase 1C Protein G9a |
| Background: | Histone methyltransferase that specifically mono- and dimethylates ‘Lys-9’ of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of ‘Lys-56’ of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates ‘Lys-27’ of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of ‘Lys-373’ of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself. |
| Form: | Liquid |
| Buffer: | Liquid form in PBS containing 50% glycerol,and 0.02% sodium azide. |
| Storage: | Store at -20°C, and avoid repeat freeze-thaw cycles. |