FAK Mouse Monoclonal Antibody
| Cat Number: | MAB-10157 |
|---|---|
| Conjugate: | Unconjugated |
| Size: | 100μg |
| Clone: | 1C4 |
| Concentration: | 1mg/ml |
| Host: | Mouse |
| Isotype: | IgG2c |
| Immunogen: | Focal adhesion kinase 1 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western Blot: 1:500-1:3000 |
| Molecular Weight: | 110 kDa |
| Purification: | Protein A+G purification |
| Synonyms: | FADK, FADK 1, FAK, FAK1, Focal adhesion kinase 1, pp125FAK, Protein tyrosine kinase 2, PTK2, PTK2 protein tyrosine kinase 2 |
| Background: | This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. |
| Form: | Liquid |
| Buffer: | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| Storage: | Store at -20℃ for 12 months (Avoid repeated freeze / thaw cycles.) |
MCF7 cells were subjected to SDS PAGE followed by western blot with FAK Antibody at dilution of 1:1000.
Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using FAK Antibody at dilution of 1:100.