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GLI-1 Rabbit Polyclonal Antibody

Cat Number: AB-84788
Conjugate: Unconjugated
Size: 100 ug
Clone: POLY
Concentration: 1mg/ml
Host: Rabbit
Isotype: IgG
Immunogen: Synthesized peptide derived from human GLI-1. at AA range: 460-490
Reactivity: Human,Mouse
Applications:

Western Blot: 1:500-2000
Molecular Weight: 120kD
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Synonyms: Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI)
Background:

This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell
proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene.

Form: Liquid
Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage: Store at -20℃. Avoid repeated freeze-thaw cycles.
AB-84788-1

Sun, Mingjuan, et al. “Hedgehog pathway is involved in nitidine chloride induced inhibition of epithelial-mesenchymal transition and cancer stem cells-like properties in breast cancer cells.” Cell & bioscience 6.1 (2016): 44.