Granzyme M Rabbit Polyclonal Antibody
| Cat Number: | ABN11744 |
|---|---|
| Conjugate: | Unconjugated |
| Size: | 100μL |
| Clone: | Polyclonal |
| Concentration: | 1mg/ml |
| Host: | Rabbit |
| Isotype: | IgG |
| Immunogen: | Synthetic peptide from human protein at AA range: 207-256 |
| Reactivity: | Human,Rat,Mouse |
| Applications: | IHC 1:50-1:200,ICC/IF 1:50-1:200,ELISA 1:10000-1:20000 |
| Purification: | Affinity purification |
| Synonyms: | Granzyme M (EC 3.4.21.-;Met-1 serine protease;Hu-Met-1;Met-ase;Natural killer cell granular protease) |
| Background: | Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and the protein encoded by this gene, granzyme M. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012],function:Cleaves peptide substrates after methionine, leucine, and norleucine.,similarity:Belongs to the peptidase S1 family. Granzyme subfamily.,similarity:Contains 1 peptidase S1 domain.,subcellular location:Granules of large granular lymphocytes., |
| Form: | Liquid |
| Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N. |
| Storage: | Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles. |