HIF Prolyl Hydroxylases Rabbit Monoclonal Antibody
| Cat Number: | MABN84748 |
|---|---|
| Conjugate: | Unconjugated |
| Size: | 100μL |
| Clone: | Monoclonal |
| Concentration: | 1mg/ml |
| Host: | Rabbit |
| Isotype: | IgG |
| Immunogen: | A synthesized peptide derived from human HIF PH4 |
| Reactivity: | Human |
| Applications: | WB 1:1000-1:2000,IHC 1:100-1:200,FC 1:20-1:100,IP 1:20-1:50 |
| Molecular: | Calculated MW: 57 kDa ; Observed MW: 47 kDa |
| Purification: | Affinity Purification |
| Synonyms: | EGLN4 ; HIFPH4; Hypoxia inducible factor prolyl 4 hydroxylase; P4H with transmembrane domain; P4htm; PH4; PHD4; Proline 4 hydroxylase; Prolyl hydroxlase domain containing 4;;HIF PH4 |
| Background: | Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at ‘Pro-402’ and ‘Pro-564’. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. |
| Form: | Liquid |
| Buffer: | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
| Storage: | Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles. |