IRE1 Rabbit Monoclonal Antibody
Cat Number: | MAB-94780 |
---|---|
Conjugate: | Unconjugated |
Size: | 100 ug |
Clone: | ARC57190 |
Concentration: | 1mg/ml |
Host: | Rabbit |
Isotype: | IgG |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 286-435 of human IRE1. |
Reactivity: | Human, Mouse, Rat |
Applications: | Western Blot: 1:500-1:1000 |
Molecular Weight: | 130kDa |
Purification: | Affinity purification |
Synonyms: | IRE1; IRE1P; IRE1a; hIRE1p |
Background: | This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins, regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1. |
Form: | Liquid |
Buffer: | PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3. |
Storage: | Store at -20℃. Avoid freeze / thaw cycles. |