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MMP-3 Rabbit Polyclonal Antibody

Cat Number: AB-84795
Conjugate: Unconjugated
Size: 100 ug
Clone: POLY
Concentration: 1mg/ml
Host: Rabbit
Isotype: IgG
Immunogen: The antiserum was produced against synthesized peptide derived from human MMP-3. AA range:421-470
Reactivity: Human, Mouse, Rat
Applications:

Western Blot: 1/500 – 1/2000.
Immunohistochemistry: 1/100 – 1/300.
Immunofluorescence: 1/200 – 1/1000.
Molecular Weight: 53kD
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Synonyms: MMP3; STMY1; Stromelysin-1; SL-1; Matrix metalloproteinase-3; MMP-3; Transin-1
Background:

matrix metallopeptidase 3(MMP3) Homo sapiens Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as
embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP’s are secreted as inactive proproteins which are activated when
cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved
in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
Form: Liquid
Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage: Store at -20°C. Avoid repeated freeze-thaw cycles.
AB-84795-1

Western blot analysis of lysates from 293 cells, using MMP-3 Antibody.
The lane on the right is blocked with the synthesized peptide.

AB-84795-2

Fan, Mengtian, et al. “CX3CL1 promotes tumour cell by inducing tyrosine phosphorylation of cortactin in lung cancer.”
Journal of Cellular and Molecular Medicine 25.1 (2021): 132-146.

AB-84795-3

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using MMP-3 Antibody. The picture on the right blocked with the synthesized peptide.