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Nesprin3 Rabbit Monoclonal antibody

Cat Number: MABN02332
Conjugate: Unconjugated
Size: 100μL
Clone: Monoclonal
Concentration: 1mg/ml
Host: Rabbit
Isotype: IgG
Immunogen: Recombinant protein of human Nesprin3
Reactivity: Human
Applications: WB 1:500-1:1000
Molecular: Calculated MW: 112 kDa; Observed MW: 112 kDa
Purification: Affinity Purified
Synonyms: KASH3; NET53; Nesp3; C14orf49; C14orf139; LINC00341; NCRNA00341
Background:

As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells.

Form: Liquid
Buffer: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.