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NeuN-FOX3

Cat Number: MAB-94416
Size: 100 UG
Clone: D4G40
Concentration: 1mg/ml
Host: Rb
Isotype: IgG
Immunogen: recombinant protein specific to the amino terminus of human NeuN protein.
Reactivity: Hu, Ms, Rt
Applications:

WB: 1:1000, ICC, IF: 1:50, IHC: 1:400

Molecular: 46-55 kDa
Purification: Purified
Background:

Neuronal nuclei (NeuN, Fox-3, RBFOX3) is a
nuclear protein expressed in most post-mitotic neurons of the
central and peripheral nervous systems. NeuN is not detected
in Purkinje cells, sympathetic ganglion cells, Cajal-Retzius
cells, INL retinal cells, inferior olivary, and dentate nucleus
neurons (1). This neuronal protein was originally identified by
immunoreactivity with a monoclonal antibody also called NeuN.
Using MS-analysis, NeuN was later identified as the Fox-3
gene product. Fox-3 contains an RNA recognition motif and
functions as a splicing regulator (2). Fox-3 regulates alternative
splicing of NumB, promoting neuronal differentiation during
development (3).

Form: Liquid
Storage: 4°C for short term and -20°C for longer term