NOX2
| Cat Number: | AB-83889 |
|---|---|
| Size: | 100 ug |
| Clone: | poly |
| Concentration: | 1mg/ml |
| Host: | Rb |
| Isotype: | IgG |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 283-570 of human Nox2 |
| Reactivity: | Hu, Ms, Rt |
| Applications: | Western Blot: 1 :500 – 1:1000 Immunohistochemistry (paraffine Embedded tissues) : 1:50-1:100 Immunofluorescence: 1:50-1:100 |
| Molecular Weight: | 65kDa |
| Purification: | Aff. Pur. |
| Synonyms: | CYBB; AMCBX2; CGD; GP91-1; GP91-PHOX; GP91PHOX; IMD34; NOX2; p91-PHOX; cytochrome b-245 beta chain |
| Background: | Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell’s respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. |
| Form: | Liquid |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Storage: | At 4°C for short term. For longer terms at -20°. Avoid freeze and thaw cycles |