OPG Rabbit Polyclonal Antibody
| Cat Number: | AB-E11701 |
|---|---|
| Conjugate: | Unconjated |
| Size: | 100 ug |
| Clone: | POLY |
| Concentration: | 1mg/ml |
| Host: | Rabbit |
| Isotype: | IgG |
| Immunogen: | The antiserum was produced against synthesizedpeptide derived from human TR11B . AA range:10-59 |
| Reactivity: | Human;Mouse |
| Applications: | Western Blot: 1/500 - 1/2000. Immunohistochemistry(paraffin-embedded tissues): 1:100-300 |
| Molecular Weight: | 55kD |
| Purification: | The antibody was affinity-purified fromrabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Synonyms: | TNFRSF11B; OCIF; OPG; Tumor necrosis factor receptor superfamily member 11B; Osteoclastogenesis inhibitory factor; Osteoprotegerin |
| Background: | The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This proteinspecifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis andvascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their |
| Form: | Liquid |
| Buffer: | Liquid in PBS containing 50% glycerol, 0.5%BSAand0.02% sodium azide. |
| Storage: | Store at -20°C. Avoid repeated freeze-thawcycles. |