PDE4C Rabbit Polyclonal Antibody
| Cat Number: | ABN15892 |
|---|---|
| Conjugate: | Unconjugated |
| Size: | 100μL |
| Clone: | Polyclonal |
| Concentration: | 1mg/ml |
| Host: | Rabbit |
| Isotype: | IgG |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human PDE4C. AA range:291-340 |
| Reactivity: | Human,Mouse,Rat |
| Applications: | WB 1:500-1:2000,IHC 1:50-1:300,ELISA 1:2000-1:20000 |
| Molecular: | 80kDa |
| Purification: | Affinity purification |
| Synonyms: | PDE4C; DPDE1; cAMP-specific 3'; 5'-cyclic phosphodiesterase 4C; DPDE1; PDE21 |
| Background: | The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011],catalytic activity:Adenosine 3′,5′-cyclic phosphate + H(2)O = adenosine 5′-phosphate.,enzyme regulation:Inhibited by rolipram.,pathway:Purine metabolism; cAMP degradation; AMP from cAMP: step 1/1.,similarity:Belongs to the cyclic nucleotide phosphodiesterase family.,tissue specificity:Expressed in various tissues but not in cells of the immune system., |
| Form: | Liquid |
| Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N. |
| Storage: | Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles. |