PHF8 Rabbit Monoclonal Antibody
| Cat Number: | MABN84004 |
|---|---|
| Conjugate: | Unconjugated |
| Size: | 100μL |
| Clone: | Monoclonal |
| Concentration: | 1mg/ml |
| Host: | Rabbit |
| Isotype: | IgG |
| Immunogen: | A synthesized peptide derived from human PHF8 |
| Reactivity: | Human,Mouse,Rat |
| Applications: | WB 1:1000-1:2000,ICC 1:50-1:200,IP 1:20-1:50 |
| Molecular: | Calculated MW: 118 kDa ; Observed MW: 140 kDa |
| Purification: | Affinity Purification |
| Synonyms: | Histone lysine demethylase PHF8; MRXSSD; PHD finger protein 8; PHF8; ZNF422;;PHF8 |
| Background: | Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 ‘Lys-9’ residue (H3K9Me1 and H3K9Me2), dimethylated H3 ‘Lys-27’ (H3K27Me2) and monomethylated histone H4 ‘Lys-20’ residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. |
| Form: | Liquid |
| Buffer: | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
| Storage: | Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles. |