Phospho-alpha Synuclein (Ser129) Rabbit Polyclonal Antibody
| Cat Number: | ABN00915 |
|---|---|
| Conjugate: | Unconjugated |
| Size: | 100ul |
| Clone: | POLY |
| Concentration: | 1mg/ml |
| Host: | Rabbit |
| Isotype: | IgG |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human Synuclein around the phosphorylation site of Ser129. AA range:91-140 |
| Reactivity: | Human,Mouse,Rat |
| Applications: | WB 1:500-1:1000,IHC 1:50-1:100 |
| Molecular: | 18 kDa |
| Purification: | Affinity purification |
| Synonyms: | SNCA; NACP; PARK1; Alpha-synuclein; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP |
| Background: | May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation. Genetic alterations of SNCA resulting in aberrant polymerization into fibrils, are associated with several neurodegenerative diseases (synucleinopathies). |
| Form: | liquid |
| Buffer: | Liquid in PBS containing 50% glycerol, 0.5% protective protein and 0.02% sodium azide, pH 7.3. |
| Storage: | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Western blot analysis of Phospho-alpha Synuclein (Ser129) in mouse brain lysates using Phospho-alpha Synuclein (Ser129) antibody.
Immunohistochemistry analysis of paraffin-embedded Human brain using Synuclein (Phospho-Ser129) antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval. Sample with blocking peptide on the right.