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Phospho-Catenin-β (S33)

Cat Number: ABP-0216
Conjugate: Unconjugated
Size: 100 ug
Clone: Poly
Concentration: 1mg/ml
Host: Rb
Isotype: IgG
Immunogen: A phospho specific peptide corresponding to residues surrounding S33 of human CTNNB1
Reactivity: Hu, Ms, Rt
Applications:

WB 1:1000

Molecular: 92 kDa
Synonyms: CTNNB; MRD19; armadillo
Background:

The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.

Form: liquid
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20° C. Avoid freeze / thaw cycles.
ABP-0216-1.jpg

Western blot analysis of extracts from MCF-7 cells using Phospho-CTNNB1-S33 Antibody