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Phospho-Catenin-β (S37)

Cat Number: ABP-0217
Conjugate: Unconjugated
Size: 100 ug
Clone: Poly
Concentration: 1mg/ml
Host: Rb
Isotype: IgG
Immunogen: A phospho specific peptide corresponding to residues surrounding Ser37 of human CTNNB1
Reactivity: Hu, Ms, Rt
Applications:

Western Blot: 1:1000 Immunohistochemistry (paraffin embedded tissues): 1:100

Molecular: 92kDa
Purification: Affinity purification
Background:

The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.

Form: liquid
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.
ABP-0217-1.jpg

Western blot analysis of extracts from HT29 cells using Phospho-CTNNB1-Ser37 antibody.

ABP-0217-2.jpg

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Phospho-CTNNB1-Ser37 antibody.