|Immunogen:||A phospho specific peptide corresponding to residues surrounding S632 of human HDAC4|
|Reactivity:||Hu, Ms, Rt|
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.
|Buffer:||PBS with 0.02% sodium azide, 50% glycerol, pH7.3.|
|Storage:||Store at -20oC or -80oC. Avoid freeze / thaw cycles.|
Western blot analysis of extracts from 293 cells using Phospho-HDAC4-S632 antibody