This gene encodes a subunit of the transcription factor complex nuclear factorkappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 fµll-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may resµlt in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing resµlts in mµltiple transcript variants.