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Phospho-NFKB-P52-S866

Cat Number: ABP-0418
Conjugate: Unconjugated
Size: 100 ug
Clone: Poly
Concentration: 1mg/ml
Host: Rb
Isotype: IgG
Immunogen: A phospho specific peptide corresponding to residues surrounding Ser866 of human NFKB-p52
Reactivity: Hu, Ms, Rt
Applications:

WB: 1:1000 IHC: 1:50 – 1:100 IF: 1:50 – 1:100

Molecular: 120 kDa
Purification: Affinity purification
Background:

This gene encodes a subunit of the transcription factor complex nuclear factorkappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 fµll-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may resµlt in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing resµlts in mµltiple transcript variants.

Form: liquid
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3, BSA.
Storage: Store at -20° C. Avoid freeze / thaw cycles.
ABP-0418-1.jpg

Western blot analysis of extracts from ovary cancer cells, using Phospho-NFKB-p52 (Ser866) antibody.

ABP-0418-2.jpg

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Phospho-NFKB-p52 (Ser866) antibody.

ABP-0418-3.jpg

Immunofluorescence staining of methanol-fixed HeLa cells using Phospho-NFKB-p52 (Ser866) Ab.