|Immunogen:||A phospho specific peptide corresponding to residues surrounding S404 of human MAPT.|
|Reactivity:||Hu, Ms, Rt|
Western blot: 1:1000 Immunohistochemistry (paraffin-embedded tissues): 1:50-1:100 Immunofluorescence : 1:50-1:200
This gene encodes the microtubμle-associated protein tau (MAPT) whose transcript undergoes complex, regμlated alternative splicing, giving rise to several Mrna species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer’s disease, Pick’s disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
|Buffer:||PBS with 0.02% sodium azide, 50% glycerol, pH7.3.|
|Storage:||Store at -20℃. Avoid freeze / thaw cycles.|
Western blot analysis of extracts from mouse brain tissue, using phospho-TAU-S404 antibody.
Immunohistochemical analysis of paraffin-embedded rat hippocampal region tissue from a model with Alzheimer, using phospho-TAU-S404 antibody.
Immunofluorescence staining of methanol-fixed Hela cells, using phospho-TAU-S404 antibody.