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Presenilin-1

Cat Number: AB-10089
Conjugate: Unconjugated
Size: 100 ug
Clone: POLY
Concentration: 1mg/ml
Host: Rb
Isotype: IgG
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human PSEN1
Reactivity: Hu,Ms,Rt
Applications:

Western Blot: 1:500 – 1:1000
Immunohistochemisty: 1:50 – 1:100

Molecular: 53kDa
Purification: Aff. Pur.
Synonyms: PSEN1; AD3; FAD; PS-1; PS1; S182; presenilin-1
Background:

Alzheimer’s disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.

Form: Liquid
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.Store at -20℃. Avoid freeze / thaw cycles.
AB-10089-1.jpg

Immunohistochemistry of paraffinembedded
human breast cancer
using PSEN1 Antibody at
dilution of 1:100 (40x lens).

AB-10089-2.jpg

Immunohistochemistry of paraffinembedded
human stomach using
PSEN1 Antibody at dilution of
1:100 (40x lens).