RAGE
| Cat Number: | AB-84300 |
|---|---|
| Conjugate: | Unconjugated |
| Size: | 100 ug |
| Clone: | POLY |
| Concentration: | 1mg/ml |
| Host: | Rb |
| Isotype: | IgG |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 41-340 of human AGER. |
| Reactivity: | Hu, Ms, Rt |
| Applications: | Western Blot: 1:1000 – 1:2000 |
| Molecular Weight: | 53kDa |
| Purification: | Aff. Pur. |
| Synonyms: | AGER;RAGE;SCARJ1 |
| Background: | The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer’s disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). |
| Form: | Liquid |
| Buffer: | PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
| Storage: | Store at -20℃. Avoid freeze / thaw cycles. |
Western blot analysis of extracts of
various cell lines, using AGER
antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-
Rabbit IgG (H+L) at 1:10000
dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in
TBST.
Detection: ECL West Pico Plus.
Exposure time: 5s.
References
Publications: Product: Rage Rabbit pAb Journal:Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie Application:WB IF:3.74 Species: Mus musculus
PMID: 32325348
Title: GJ-4 alleviates Aβ25-35-induced memory dysfunction in mice through protecting the neurovascular unit