RAP80 Rabbit Monoclonal Antibody
| Cat Number: | MABN03180 |
|---|---|
| Conjugate: | Unconjugated |
| Size: | 100μL |
| Clone: | Monoclonal |
| Concentration: | 1mg/ml |
| Host: | Rabbit |
| Isotype: | IgG |
| Immunogen: | A synthetic peptide of human RAP80 |
| Reactivity: | Human |
| Applications: | WB 1:500-1:1000,IHC 1:50-1:100,ICC/IF 1:50-1:200 |
| Molecular: | Calculated MW: 80 kDa; Observed MW: 80 kDa |
| Purification: | Affinity Purification |
| Synonyms: | RAP80; X2HRIP110 |
| Background: | Ubiquitin-binding protein that specifically recognizes and binds ‘Lys-63’-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding ‘Lys-63’-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). |
| Form: | Liquid |
| Buffer: | 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage: | Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles. |