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SDHB

Cat Number: MAB-94592
Size: 100 ug
Clone: SDH
Concentration: 1mg/ml
Host: Rb
Isotype: IgG
Immunogen: A synthesized peptide derived from human SDHB
Reactivity: Hu, Ms, Rt
Applications: Western Blot: 1:500 - 1:2000
Molecular Weight: 32kDa
Purification: Aff. Pur.
Synonyms: CWS2; IP; PGL4; SDH; SDH1; SDH2; SDHIP
Background:

Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.

Form: Liquid
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.