SLINGSHOT-1L Mouse Monoclonal Antibody
| Cat Number: | MABN81430 |
|---|---|
| Conjugate: | Unconjugated |
| Size: | 100μL |
| Clone: | Monoclonal |
| Concentration: | 1mg/ml |
| Host: | Mouse |
| Isotype: | Mouse IgG1 |
| Immunogen: | Synthesized peptide fragment of human SLINGSHOT-1L (AA: 1032-1044 ) expressed in E. Coli. |
| Reactivity: | Human |
| Applications: | ICC 1:200-1:1000,ELISA 1:5000-1:20000,FC 1:200-1:400 |
| Molecular: | 115.5kDa |
| Purification: | Affinity Purification |
| Synonyms: | SSH1;SSH1L |
| Background: | The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
| Form: | Liquid |
| Buffer: | Purified antibody in PBS with 0.05% sodium azide |
| Storage: | Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles. |