TA2R Rabbit Polyclonal Antibody
| Cat Number: | ABN18584 |
|---|---|
| Conjugate: | Unconjugated |
| Size: | 100μL |
| Clone: | Polyclonal |
| Concentration: | 1mg/ml |
| Host: | Rabbit |
| Isotype: | IgG |
| Immunogen: | Synthesized peptide derived from human protein . at AA range: 230-310 |
| Reactivity: | Human,Rat,Mouse |
| Applications: | WB 1:500-1:2000,ELISA 1:5000-1:20000 |
| Molecular: | 37kDa |
| Purification: | Affinity purification |
| Background: | thromboxane A2 receptor(TBXA2R) Homo sapiens This gene encodes a member of the G protein-coupled receptor family. The protein interacts with thromboxane A2 to induce platelet aggregation and regulate hemostasis. A mutation in this gene results in a bleeding disorder. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009],disease:Defects in TBXA2R are the cause of a dominantly inherited bleeding disorder [MIM:188070].,function:Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase, isoform 2 inhibits adenylyl cyclase.,similarity:Belongs to the G-protein coupled receptor 1 family., |
| Form: | Liquid |
| Buffer: | Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N. |
| Storage: | Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles. |