Thrombomodulin Rabbit Monoclonal Antibody
| Cat Number: | MABN01431 |
|---|---|
| Conjugate: | Unconjugated |
| Size: | 100μL |
| Clone: | Monoclonal |
| Concentration: | 1mg/ml |
| Host: | Rabbit |
| Isotype: | IgG |
| Immunogen: | A synthetic peptide of human Thrombomodulin |
| Reactivity: | Human |
| Applications: | WB 1:500-1:1000,ICC/IF 1:50-1:200,IP 1:20-1:50 |
| Molecular: | Calculated MW: 60 kDa; Observed MW: 95 kDa |
| Purification: | Affinity Purification |
| Synonyms: | CD141; Fetomodulin; THBD; THRM; thrombomodulin; TM |
| Background: | Thrombomodulin (TM), also called CD141, is a type I membrane receptor that is specific to endothelial cells. TM has a cysteine-rich extracellular domain with six EGF-like regions. It forms a complex with Thrombin, which activates Protein C to generate activated Protein C (APC), an anticoagulant enzyme. APC together with Protein S inhibits coagulation by inactivating Factors Va and VIIIa. Deletion of the TM gene results in embryonic lethality in mice. |
| Form: | Liquid |
| Buffer: | 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage: | Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles. |