TIMAP Rabbit Polyclonal Antibody
| Cat Number: | ABN18945 |
|---|---|
| Conjugate: | Unconjugated |
| Size: | 100μL |
| Clone: | Polyclonal |
| Concentration: | 1mg/ml |
| Host: | Rabbit |
| Isotype: | IgG |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human PPP1R16B. AA range:364-413 |
| Reactivity: | Human,Mouse |
| Applications: | WB 1:500-1:2000,IHC 1:50-1:300 |
| Molecular: | 64kDa |
| Purification: | Affinity purification |
| Synonyms: | PPP1R16B; ANKRD4; KIAA0823; Protein phosphatase 1 regulatory inhibitor subunit 16B; Ankyrin repeat domain-containing protein 4; CAAX box protein TIMAP; TGF-beta-inhibited membrane-associated protein; hTIMAP |
| Background: | The protein encoded by this gene is membrane-associated and contains five ankyrin repeats, a protein phosphatase-1-interacting domain, and a carboxy-terminal CAAX box domain. Synthesis of the encoded protein is inhibited by transforming growth factor beta-1. The protein may bind to the membrane through its CAAX box domain and may act as a signaling molecule through interaction with protein phosphatase-1. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015],function:May be a downstream target for TGF-beta1 signaling cascade in endothelial cells.,induction:Inhibited by TGF-beta1.,similarity:Contains 5 ANK repeats.,subunit:Binds PP1.,tissue specificity:Highly expressed in vascular endothelium, CNS, lung, spleen, kidney and testis., |
| Form: | Liquid |
| Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N. |
| Storage: | Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles. |