TRIM24 Rabbit Monoclonal Antibody
| Cat Number: | MABN03240 |
|---|---|
| Conjugate: | Unconjugated |
| Size: | 100μL |
| Clone: | Monoclonal |
| Concentration: | 1mg/ml |
| Host: | Rabbit |
| Isotype: | IgG |
| Immunogen: | Recombinant protein of human TRIM24 |
| Reactivity: | Human |
| Applications: | WB 1:500-1:1000 |
| Molecular: | Calculated MW: 117 kDa; Observed MW: 117 kDa |
| Purification: | Affinity Purification |
| Synonyms: | PTC6; TF1A; TIF1; RNF82; TIF1A; hTIF1; TIF1ALPHA |
| Background: | Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at ‘Lys-4’ (H3K4me0) and acetylated at ‘Lys-23’ (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes . |
| Form: | Liquid |
| Buffer: | 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage: | Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles. |