TRIM29 (18R2) Rabbit Monoclonal Antibody
| Cat Number: | MABN19272 |
|---|---|
| Conjugate: | Unconjugated |
| Size: | 100μL |
| Clone: | Monoclonal |
| Concentration: | 1mg/ml |
| Host: | Rabbit |
| Isotype: | IgG |
| Immunogen: | A synthetic peptide of human TRIM29 |
| Reactivity: | Human,Mouse,Rat |
| Applications: | WB 1:1000-1:5000 |
| Molecular: | 66kDa |
| Purification: | Affinity purification |
| Synonyms: | ATDC; TRIM29; |
| Background: | It is able to complement the radiosensitivity defect of an ataxia telangiectasia (AT) fibroblast cell line. Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its ‘Lys-48’ ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of proinflammatory cytokines are inhibited. Additionally, induces the ‘Lys-48’ ubiquitination of STING1 in a similar way, leading to its degradation. |
| Form: | Liquid |
| Buffer: | Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA. |
| Storage: | Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles. |