U1C Rabbit Monoclonal Antibody
| Cat Number: | MABN02735 |
|---|---|
| Conjugate: | Unconjugated |
| Size: | 100μL |
| Clone: | Monoclonal |
| Concentration: | 1mg/ml |
| Host: | Rabbit |
| Isotype: | IgG |
| Immunogen: | A synthetic peptide of human U1-C |
| Reactivity: | Human,Rat |
| Applications: | WB 1:500-1:1000,IHC 1:50-1:100,ICC/IF 1:50-1:200,IP 1:20-1:50 |
| Molecular: | Calculated MW: 17 kDa; Observed MW: 21 kDa |
| Purification: | Affinity Purification |
| Synonyms: | U1 small nuclear ribonucleoprotein C; U1 snRNP C; U1-C |
| Background: | Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5′ splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5′ splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5′ splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5′ end of the U1 snRNA and the 5′ splice-site region. |
| Form: | Liquid |
| Buffer: | 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage: | Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles. |