UBA3 Rabbit Monoclonal Antibody
| Cat Number: | MABN84768 |
|---|---|
| Conjugate: | Unconjugated |
| Size: | 100μL |
| Clone: | Monoclonal |
| Concentration: | 1mg/ml |
| Host: | Rabbit |
| Isotype: | IgG |
| Immunogen: | A synthesized peptide derived from human UBA3 |
| Reactivity: | Human,Mouse,Rat |
| Applications: | WB 1:1000-1:2000 |
| Molecular: | Calculated MW: 52 kDa ; Observed MW: 50 kDa |
| Purification: | Affinity Purification |
| Synonyms: | hUba3; NEDD8 activating enzyme E1C; uba3; UBE1C;;UBA3 |
| Background: | Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression. |
| Form: | Liquid |
| Buffer: | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
| Storage: | Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles. |