XPC Mouse Monoclonal Antibody
| Cat Number: | MABN82915 |
|---|---|
| Conjugate: | Unconjugated |
| Size: | 100μL |
| Clone: | Monoclonal |
| Concentration: | 1mg/ml |
| Host: | Mouse |
| Isotype: | Mouse IgG1 |
| Immunogen: | Purified recombinant fragment of human XPC (AA: 32-133) expressed in mammalian. |
| Reactivity: | Human |
| Applications: | WB 1:500-1:2000,IHC 1:200-1:1000,ICC 1:50-1:200,ELISA 1:5000-1:20000,FC 1:200-1:400 |
| Molecular: | 106kDa |
| Purification: | Affinity Purification |
| Synonyms: | XP3; RAD4; XPCC; p125 |
| Background: | The protein encoded by this gene is a key component of the XPC complex, which plays an important role in the early steps of global genome nucleotide excision repair (NER). The encoded protein is important for damage sensing and DNA binding, and shows a preference for single-stranded DNA. Mutations in this gene or some other NER components can result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene. |
| Form: | Liquid |
| Buffer: | Purified antibody in PBS with 0.05% sodium azide |
| Storage: | Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles. |
