ZAP70 (4B2) Mouse Monoclonal Antibody
| Cat Number: | MABN03513 |
|---|---|
| Conjugate: | Unconjugated |
| Size: | 100μL |
| Clone: | Monoclonal |
| Concentration: | 1mg/ml |
| Host: | Mouse |
| Isotype: | IgG2b |
| Immunogen: | A synthetic peptide corresponding to target protein |
| Reactivity: | Human |
| Applications: | WB 1:500-1:1000,IP 1:20-1:50 |
| Molecular: | Calculated MW: 70 kDa; Observed MW: 70 kDa |
| Purification: | Affinity Purification |
| Synonyms: | ZAP70; SRK; Tyrosine-protein kinase ZAP-70; 70 kDa zeta-chain associated protein; Syk-related tyrosine kinase |
| Background: | The Syk family protein tyrosine kinase Zap-70 is expressed in T and NK cells and plays a critical role in mediating T cell activation in response to T cell receptor (TCR) engagement. Following TCR engagement, Zap-70 is rapidly phosphorylated on several tyrosine residues through autophosphorylation and transphosphorylation by the Src family tyrosine kinase Lck. |
| Form: | Liquid |
| Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. |
| Storage: | Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles. |