14.3.3n (eta) Mouse Monoclonal Antibody
| Cat Number: | MAB-94073 |
|---|---|
| Conjugate: | Unconjugated |
| Size: | 100 ug |
| Clone: | 3G12 |
| Concentration: | 1mg/ml |
| Host: | Mouse |
| Isotype: | IgG1 |
| Immunogen: | Full length human recombinant 14-3-3η (eta) protein expressed in and purified from E.coli. |
| Reactivity: | Hu, Rt, Ms, Co, Pg, Dg |
| Applications: | Western Blot: 1:1,000-1:5,000. Immunocytochemistry:1:500-1:1,000 Immunofluorescence: 1:500-1:1,000 Immunohistochemistry: 1:500-1:1,000 |
| Molecular Weight: | 28 kDA |
| Purification: | Purified |
| Background: | The 14.3.3 family proteins were originally discovered as prominent protein spots on 2 dimensional gels. They are a family of 28-33 kDa proteins which make up the major portion of cytoplasm proteins. They function as binding partners for phosphoserine and phosphothreonine sites in other proteins, though they have other binding partners which are not dependent on phosphorylation. 14.3.3η or 14.3.3 eta is widely expressed and concentrated in the nervous system. The 14.3.3η protein accumulates in the CSF of patients suffering from Creutzfeld Jacob Disease, and can be used for the diagnosis of this disease. Furthermore, this protein binds α-synuclein in the Lewy bodies of Parkinson’s disease and has been linked to early-onset schizophrenia. |
| Form: | Liquid |
| Buffer: | Purified antibody at 1mg/mL in 50% PBS, 50% glycerol plus 5mM NaN3 |
| Storage: | Store at 4°C for short term. For long term storage, please leave frozen at -20°C and avoid freeze/thaw cycles. |