APC Rabbit Monoclonal antibody
| Cat Number: | MABN02900 |
|---|---|
| Conjugate: | Unconjugated |
| Size: | 100μL |
| Concentration: | 1mg/ml |
| Host: | Rabbit |
| Isotype: | IgG |
| Immunogen: | A synthetic peptide of human APC |
| Reactivity: | Human |
| Applications: | WB 1:500-1:1000,ICC/IF 1:50-1:200,IP 1:20-1:50 |
| Molecular: | 160 kDa |
| Purification: | Affinity purification |
| Synonyms: | APC; DP2.5; Adenomatous polyposis coli protein; Protein APC; Deleted in polyposis 2.5 |
| Background: | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. |
| Form: | liquid |
| Buffer: | 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein |
| Storage: | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Immunocytochemistry analysis of APC (green) in LNcap using APC antibody, and DAPI (blue).
Western blot analysis of APC in Hela, A549, HL-60, U2OS lysates using APC antibody.