BACE1
Cat Number: | AB-84297 |
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Conjugate: | Unconjugated |
Size: | 100 ug |
Clone: | POLY |
Concentration: | 1mg/ml |
Host: | Rb |
Isotype: | IgG |
Immunogen: | allograft inflammatory factor |
Reactivity: | Hu, Ms, Rt |
Applications: | Western Blot: 1:500-1:2000 |
Molecular Weight: | 17kDa |
Purification: | Aff. Pur. ≥95% as determined by SDS-PAGE |
Synonyms: | AIF 1, AIF1, G1, IBA1, IRT 1, Protein G1 |
Background: | AIF1, also named as G1, IBA1 or daintain/AIF-1, is a 143 amino acid cytoplasmic, inflammation response scaffold protein. It is constitutively expressed in monocytes and macrophages and is known to be involved in macrophage activation. It is a marker of activated macrophage. Despite a lack of detailed knowledge on the in vivo physiological functions of AIF-1, there is growing evidence that shows its aberrant expression contributes to the pathogenesis of many autoimmune diseases, including rheumatoid arthritis. (20944424). AIF1 is an actin-binding protein that enhances membrane ruffling and RAC activation. It enhances lymphocyte migration and the actin-bundling activity of LCP1. AIF1 plays a role in RAC signaling and in phagocytosis and a role in vascular inflammation. AIF1 promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. It is also as a microglial cell marker. |
Form: | Liquid |
Buffer: | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.) |
mouse spleen tissue were subjected to SDS PAGE followed by western blot with (IBA1 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human tonsillitis using (IBA1 antibody) at dilution of 1:50
Immunofluorescent analysis of ( -20℃ Ethanol ) fixed C6 cells using ( IBA1 Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated Goat Anti-Rabbit IgG(H+L)