BCL-2
| Cat Number: | AB-81822 |
|---|---|
| Conjugate: | Unconjugated |
| Size: | 100 ug |
| Clone: | POLY |
| Concentration: | 1mg/ml |
| Host: | Rb |
| Isotype: | IgG |
| Immunogen: | Synthesized peptide derived from human Bcl-2 around the nonphosphorylation site of T69. Immunogen Region 20-100 aa. |
| Reactivity: | Hu, Ms, Rt |
| Applications: | WB: 1:1000-1:2000 |
| Molecular Weight: | 26 kDa |
| Purification: | Aff. Pur. |
| Background: | Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release . |
| Form: | Liquid |
| Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Storage: | Store at -20°C,and avoid repeat freeze-thaw cycles. |
Western Blot (WB) analysis of specific cells using Bcl-2 Polyclonal Antibody.