Catenin alpha-1/CTNNA1
| Cat Number: | MAB-94590 |
|---|---|
| Size: | 100 ug |
| Clone: | alpha-CAT-7A4 |
| Concentration: | 1mg/ml |
| Host: | Ms |
| Isotype: | IgG1 |
| Immunogen: | catenin(cadherin-associated protein), alpha 1, 102kDa |
| Reactivity: | Hu, Ms |
| Applications: | Western Blot: 1:500-1:2000 |
| Molecular Weight: | 95-100kDa |
| Purification: | Protein A+G purification . |
| Synonyms: | Alpha E catenin, Cadherin associated protein, CAP102, Catenin alpha 1, CTNNA1 |
| Background: | Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E-and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation. |
| Form: | Liquid |
| Buffer: | PBS with 0.02% sodium azide and 50% glycerol pH 7.3 |
| Storage: | Storage-20℃ for 12 months (Avoid repeated freeze / thaw cycles.) T483 |
NIH/3T3 cells were subjected to SDS PAGE followed by western blot with (CTNNA1 Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human stomach tissue slide using (CTNNA1 Antibody) at dilution of 1:200