CDKN1B
Cat Number: | AB-82085 |
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Conjugate: | Unconjugated |
Size: | 100 ug |
Clone: | POLY |
Concentration: | 1mg/ml |
Host: | Rabbit |
Isotype: | IgG |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-198of human CDKN1B/p27KIP1 (NP_004055.1). |
Reactivity: | Hu, Ms, Rt |
Applications: | Western Blot: 1:500 - 1:2000 Immunohistochemsitry: 1:50 - 1:200 Immunofluorescence: 1:20 - 1:50 |
Molecular Weight: | 27kDa |
Purification: | Aff. Pur. |
Synonyms: | CDKN1B;CDKN4;KIP1;MEN1B;MEN4;P27KIP1;p27 KIP 1 |
Background: | This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). |
Form: | Liquid |
Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
Storage: | Store at -20℃. Avoid freeze / thaw cycles. |