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Cytochrome P450 Rabbit Monoclonal Antibody

Cat Number: MAB-94795
Conjugate: Unconjugated
Size: 100 ug
Clone: ARC58001
Concentration: 1mg/ml
Host: Rabbit
Isotype: IgG
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 234-493 of human Cytochrome P450 2E1
Reactivity: Human, Mouse, Rat
Applications: Immunohistochemistry (paraffin-embedded tissues): 1:500 - 1:1000 Immunofluorescence: 1:50 - 1:200
Molecular Weight: 57kDa
Purification: Affinity purification
Synonyms: CPE1; CYP2E; P450-J; P450C2E
Background:

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.

Form: Liquid
Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.