Fibronectin
| Cat Number: | MAB-10538 |
|---|---|
| Size: | 100 ug |
| Clone: | BLAb52 |
| Concentration: | 1mg/ml |
| Host: | Ms |
| Isotype: | IgG1 |
| Reactivity: | Hu |
| Applications: | Elisa: 2-10 ug/ml |
| Purification: | Purified |
| Background: | Fibronectin is a multifunctional glycoprotein present in connective tissues and plasma. Fibronectin mediates cell adhesion and migration during embryonic development, wound healing in adult tissues. A soluble form of fibronectin is present in blood plasma and other body fluids such as synovial and tear fluids. Plasma fibronectin is a potent opsonizing factor promoting phagocytosis of tissues and collagen debris by macrophages. |
| Form: | Liquid |
| Buffer: | The antibody is purified on ProteinA-Sepharose and it is desolved in PBS with 0.05% sodium azide as preservative. At this concentration azide will be toxic to most cellular systems. If necessary it can be removed through dialysis against an appropriate buffer prior to use. |
| Storage: | The antibody can be stored frozen at -20°C. |
References
Tarone G, Amedeo MR, Di Renzo MF, Comoglio P. Monoclonal antibodies to the collagen binding domain of human plasma fibronectin. Exp Cell Biol. 1984;52(4):225-36.
-Ruoslahti E. Fibronectin and its integrin receptors in cancer. Adv Cancer Res. 1999;76:1-20.
-Armstrong PB, Armstrong MT. Intercellular invasion and the organizational stability of tissues: a role for fibronectin. Biochim Biophys Acta. 2000 Mar 27;1470(2):O9-20.
-Barilla ML, Carsons SE. Fibronectin fragments and their role in inflammatory arthritis. Semin Arthritis Rheum. 2000 Feb;29(4):252-65.
-Andersen HF. Use of fetal fibronectin in women at risk for preterm delivery. Clin Obstet Gynecol. 2000 Dec;43(4):746-58. AK1540