IGF1R Rabbit Polyclonal Antibody
Cat Number: | AB-81364 |
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Conjugate: | Unconjugated |
Size: | 100μg |
Clone: | POLY |
Concentration: | 1mg/ml |
Host: | Rabbit |
Isotype: | IgG |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1201-1367 of human IGF1R. |
Reactivity: | Human,Mouse,Rat |
Applications: | Western Blot: 1:1000 - 1:5000 |
Molecular Weight: | 100kDa |
Purification: | Affinity purification |
Synonyms: | IGFR; CD221; IGFIR; JTK13; 1R |
Background: | This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. |
Form: | Liquid |
Buffer: | PBS with 0.01% thimerosal,50% glycerol,pH7.3. |
Storage: | At 4°C for one month. Or store frozen at -20°C for a longer time. Avoid freezing and thawing. |