Interleukin-1 Beta Rabbit Monoclonal Antibody
| Cat Number: | MAB-94634 |
|---|---|
| Conjugate: | Unconjugated |
| Size: | 100 ug |
| Clone: | MI1 |
| Concentration: | 1mg/ml |
| Host: | Rabbit |
| Isotype: | IgG |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the Internal region of human IL1B. AA range:181-230 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western Blot: 1:500 - 1:2000 Immunofluorescence: 1:50 – 1:200 Immunohistochemistry (paraffin-embedded tissues) 1:100-300 |
| Molecular: | 17kDa |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Synonyms: | IL-1;IL1-BETA;IL1F2;IL1 beta;IL1B |
| Background: | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. |
| Form: | Liquid |
| Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Storage: | Store at -20℃. Avoid freeze / thaw cycles. |